Androgens and Sebum Production

Acne Vulgaris

The majority of potent androgens are produced by peripheral target tissues. For example, in postmenopausal women, 100 of active sex steroids are synthesized in peripheral target tissues from inactive steroid precursors while in adult men approximately 50 of androgens are locally made in intracrine target tissues 4 . The major androgens that interact with the androgen receptor are testosterone and dihydrotestosterone. Androgen receptors have been localized to the basal layer of the sebaceous...