Abstract

Acne No More Ebook

Cure Acne Permanently

Get Instant Access

There is ample clinical evidence suggesting that the nervous system such as emotional stress can influence the course of acne. We examined possible participation of cutaneous neurogenic factors including neuropeptides, neuropeptide-degrading enzymes and neurotrophic factors, in association with inflammation in the pathogenesis of acne. Immunohistochemical studies revealed that substance P (SP)-immunoreactive nerve fibers were in close apposition to the sebaceous glands, and that neutral endopeptidase (NEP) was expressed in the germina-tive cells of the sebaceous glands in the skin from acne patients. Nerve growth factor showed immunoreactivity only within the germinative cells. In addition, an increase in the number of mast cells and a strong expression of endothelial leukocyte adhesion molecule-1 on the postcapillary venules were observed in adjacent areas to the sebaceous glands. In vitro, the levels and the expression of stem cell factor by fibroblasts were upregulated by SP. When organ-cultured normal skin specimens were exposed to SP, we observed significant increases in the sizes of the sebaceous glands and in the number of sebum vacuoles in sebaceous cells. Furthermore, supplementation of SP to organ-cultured skin induced expression of NEP, and we demonstrated the subcellular localization of NEP in the endoplasmic reticulum and the Golgi apparatus within the sebaceous germinative cells using preembedding immunoelectron microscopy. These findings suggest that SP may stimulate lipogene-sis of the sebaceous glands which may be followed by proliferation of Propionibacterium acnes, and may yield a potent influence on the sebaceous glands by provocation of inflammatory reactions via mast cells. Thus, cutaneous neurogenic factors should contribute to onset and/or exacerbation of acne inflammation.

Copyright © 2003 S. Karger AG, Basel

Acne vulgaris is a skin disorder of the sebaceous follicles that commonly occurs in adolescence and young adulthood. Many lines of clinical evidence suggest that components of the nervous system, such as psychological and neurogenic factors, can influence the course of acne [1-3]. The disease has been reported to be initiated and/or exacerbated as a result of emotional or psychosocial stress. However, the nature of the association between stress and acne remains unclear, due in part to a lack of substantial evidence regarding the participation of cutaneous neurogenic factors in the pathogenesis of acne.

Was this article helpful?

0 0
How To Cure Acne

How To Cure Acne

This information has helped thousands of people understand their acne, and subsequently make it disappear! If you are in need of comprehensive information on every aspect of acne, there is no better resource.

Get My Free Ebook


Post a comment