We have made reference to less common therapies used in clinical forms of acne. Even though some of them may be rather infrequent nowadays, they are worth considering on the following grounds: (a) cases of hypersensi-bility reactions or allergy to drugs; (b) high cost of the drugs which render them unaffordable to large sectors of the population not covered by health insurance plans, even in industrialized countries, or to poor people in emerging countries; (c) unavailability of the drug in the local pharmaceutical market.
We have also mentioned new methods using high cost equipment for which, in our opinion, more clinical studies are still needed. Finally, in our experience, the satisfactory results obtained with the combined use of isotreti-noin and methylprednisone allow us to conclude that this should be the therapy of choice in the very severe inflammatory acne, to prevent the appearance of a dreadful complication such us the one posed by 'pseudo' acne ful-minans.
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