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Despite the interest on the development of topical treatments for acne in the last decades [30], systemic treatment is still a milestone, especially in the treatment of moderate-to-severe scarring types of the disease. The establishment of new systemic drugs for acne is based on the consideration of successes and pitfalls of the past and the emerging knowledge of the future [125]. Among all pathogenetic factors of acne, inflammation seems to be rediscovered [13] and anti-inflammatory concepts seem to become the new trend of systemic and topical acne treatment.

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Dermatology 2003;206:54-56 DOI: 10.1159/000067822

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