Chemotherapeutic treatment

Chemotherapy would appear to be the method of choice in dealing with infections caused by atypical isolates (Csaba et al., 1984; Böhm et al, 1986;

Pedersen et al., 1994), although there are reports that, in some instances, chemotherapy may be difficult or ineffective (Dalsgaard and Paulsen, 1986; Whittington and Cullis, 1988; Groman et al., 1992). New antibiotics are being evaluated; for example, Heo and Seo (1996) have found that ciprofloxacin can be effective in protecting carp against infection with an atypical carp isolate. As with typical strains, development of antibiotic resistance has been recognized in atypical A. salmonicida. Hirvela-Koski et al. (1994) reported resistance to sulphonamides, and strains isolated from turbot (Pedersen et al., 1994) were found to be resistant to trimethoprim. In addition, Sandaa and Enger (1996) found that a plasmid encoding for multiple antibiotic resistance could be transferred from atypical strains to several marine bacteria.

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