Alphatocopherol And Ethanol Consumption

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Chronic alcohol consumption produces an increased breakdown oflipid-soluble vitamins such as hepatic alpha-tocopherol, possibly secondary to a marked increase in the formation ofhepatic alpha-tocopherol quinone, a metabolite of alpha-tocopherol formed by free radical reaction [82], Since chronic ethanol consumption has been associated with compromised antioxidant status and an increase in lipid peroxidation, the significant decrease of vitamin E compared to other lipid-soluble antioxidants may contribute, at least in part, to enhanced hepatic lipid peroxidation seen in alcoholics. Besides vitamin E, other antioxidants such as vitamin C, glutathione and selenium are also strikingly decreased following chronic ethanol ingestion [83 ]. It is also interesting that chronic alcohol consumption significantly alters the distribution of alpha-tocopherol and gamma-tocopherol not only in hepatic tissue but in extrahepatic tissues as well [84],

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