Nikhil Gokhale Anjali Patwardhan and J A Cowan

Department of Chemistry, Ohio State University, Columbus, OH 43210

8.1. Introduction 236

8.2. Copper(II)-Aminoglycosides 239

8.2.1. Copper(II)-Neamine 239

8.2.2. Copper(II)-Kanamycin A 240

8.2.3. Copper(II)-Kanamycin B 241

8.2.4. Copper(II)-Neomycin B 242

8.2.5. Copper(II)-Tobramycin 243

8.2.6. Copper(II)-Amikacin 244

8.2.7. Copper(II)-Geneticin 245

8.2.8. Copper(II)-Gentamicin 246

8.3. Zinc(II)-Aminoglycosides 248

8.4. Iron(III/II)-Aminoglycosides 249

8.4.1. Iron(III)-Gentamicin 249

8.5. Biological Pertinent Chemistry of Metalloaminoglycosides 250 8.5.1. Oxidative Chemistry of Metalloaminoglycosides 250

8.6. Conclusions 251 Acknowledgment 252 References 252

Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery, Second Edition, by Dev P. Arya Copyright © 2007 John Wiley & Sons, Inc.

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