Amylin Concentrations in Other Conditions

Elevated plasma amylin concentrations are observed in hypertension (Dimsdale et al., 1996; Kailasam et al., 1995; Kautzky-Willer et al., 1994; Pacini et al., 1993), a condition also associated with insulin resistance (Ferrannini et al., 1990) and hyperinsulinemia (Welborn et al., 1966). Plasma amylin concentrations are also elevated in primary hyperparathyroidism (Valdemarsson et al., 1996), another condition associated with insulin resistance.

Elevations of plasma amylin concentration are reported in patients with renal failure (Ludvik et al., 1994; Watschinger et al., 1992). In this case, however, the elevation likely reflects reduced renal amylin clearance in those patients rather than increased secretion. Nephrectomy markedly reduces clearance of amylin and pramlintide in rats (Smith et al., 1996; Vine et al., 1996,1998), indicating a major role for the kidney in clearance of circulating amylin.

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