Surgical drainage followed by placement of indwelling drains is the procedure of choice. CT-guided drainage is an option in those who cannot tolerate an open procedure. Systemic antimicrobials effective against the commonly recovered aerobic and anaerobic should be administrated (see previous section). Carbapenems are active against all likely pathogens and penetrate well into pancreatic tissue. Other antibiotics that have been shown to be efficacious in ANP include amikacin, cefuroxime, ceftazidime, and metronidazole (19).
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