Predisposing conditions include trauma (e.g., foreign body, corneal laceration, and contact lens), corneal exposure (facial palsy, sedated or moribund state, globe prostosis, congenital abnormalities of the eyelids), immune deficiency (immunodeficiency syndrome, immunosuppressive therapy, topical steroids), and abnormalities of ocular surface (dryness, mucin deficiency, vitamin A deficiency, malnutrition, and corneal anesthesia).

Anaerobic bacteria can reach the cornea from the mucous membranes in similar manner to the one discussed in the section on conjunctivitis. However, in cases of trauma or foreign body associated infection they can be directly inoculated.

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