Genetics of Cloacal Exstrophy

Cloacal Exstrophy may be a spontaneous error of development that is due to either a somatic mutation or a complex gene-environment interaction [17]. However, within a group of 232 families, 4 multiplex families were identified, suggesting some genetic component in the causation of these anomalies. A single case report of cloacal exstrophy due to an unbalanced translocation between the long arm of chromosome 9 and the long arm of the Y chromosome lends further support to this hypothesis [18]. In a review of 22 cases of cloacal exstrophy, Husmann reported 1 female with trisomy 21 and 1 mosaic (45XO/46XX) [19].

In a series of six fetuses with cloacal exstrophy examined at the Fetal Care Research Foundation, one genetic anomaly was identified (Table. 14.1).

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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