Bcl2 Augmerosen Oblimersen G3139 Genasense

bcl-2 family members represent promising targets for an antisense approach in oncology. The apoptosis inhibitor bcl-2 was discovered as a protooncogene found at the break points of t(14;18) chromosomal translocations in low-grade B-cell non-Hodgkin's lymphomas (NHL). Overexpression of bcl-2 was found in most follicular lymphomas, in some cases of diffuse large cell lymphomas, and in chronic lymphocytic leukemia (B-cell lymphatic leukemia [B-CLL]) (14). The oncogenic impetus of increased bcl-2 expression was verified in bcl-2 transgenic mice. These mice accumulated excess noncycling mature B-lym-phocytes (14). High levels of bcl-2 are associated with relapse in acute myelogenous leukemia (AML) and acute lymphocytic leukemia (11). The bcl-2

Table 2:

AS-ODNs in Clinical Trials or Approved in Hematology and Oncology



Protein target

Vitravene (fomivirsen)

Genasense (augmerosen, oblimersen, G3139)

Isis, Carlsbad, CA

(www.isispharmaceuticals.com) Ciba Vision (www.cibavision.com)

Genta, Berkeley Heights, NJ (www.genta.com)

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