Bcl2 Augmerosen Oblimersen G3139 Genasense

bcl-2 family members represent promising targets for an antisense approach in oncology. The apoptosis inhibitor bcl-2 was discovered as a protooncogene found at the break points of t(14;18) chromosomal translocations in low-grade B-cell non-Hodgkin's lymphomas (NHL). Overexpression of bcl-2 was found in most follicular lymphomas, in some cases of diffuse large cell lymphomas, and in chronic lymphocytic leukemia (B-cell lymphatic leukemia [B-CLL]) (14). The oncogenic impetus of increased bcl-2 expression was verified in bcl-2 transgenic mice. These mice accumulated excess noncycling mature B-lym-phocytes (14). High levels of bcl-2 are associated with relapse in acute myelogenous leukemia (AML) and acute lymphocytic leukemia (11). The bcl-2

Table 2:

AS-ODNs in Clinical Trials or Approved in Hematology and Oncology

Compound

Company

Protein target

Vitravene (fomivirsen)

Genasense (augmerosen, oblimersen, G3139)

Isis, Carlsbad, CA

(www.isispharmaceuticals.com) Ciba Vision (www.cibavision.com)

Genta, Berkeley Heights, NJ (www.genta.com)

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