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Drug Exposure (AUC) |jg*hr/mL

Drug Exposure (AUC) |jg*hr/mL

Fig. 1. Change (A) in CDAI and (B) IBDQ scores at wk 14, segregated by AUC cohort. Diamonds reflect the 95% confidence intervals and bars signify 1 or 2 SDs. CDAI and IBDQ significantly improved for the high-AUC subgroup vs placebo (p = 0.027 for both). (Reproduced with permission from ref. 12.)

anticipated, transient aPTT elevations of approx 3, 5, and 10 s occurred after doses of 0.5, 1.0, and 2.0 mg/kg, respectively. Moreover, we found that the clinical outcome changes were corroborated by an overall reduction in intestinal mucosal ICAM-1 expression after treatment with the 2 mg/kg dose.

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