Creatine Kinase Bbisozyme

The BB-isozyme of creatine kinase has been also investigated as a potential marker for aortic dissection since it is abundantly present both in smooth-muscle fibers and in the neurological system. Analogous to the use of the MB-isozyme of creatine kinase for the detection of cardiac ischemia, a small study has shown that creatine kinase BB-isozyme is elevated in acute aortic dissection15. In addition, the study demonstrated that the temporal profiles of the peak level is delayed compared to smooth-muscle myosin heavy chain. Combined use of the two tests may therefore be extremely useful for temporal profiling of aortic dissection.

ng/ml

Figure 16.3. (a) Plasmatic levels detected by ELISA of metalloproteinase-9 from symptom onset to two months' follow-up in type B aortic dissection. No MMP-9 are measurable in the control population presenting in the emergency room with chest pain.

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