Contents

VII Preface

Section I - Pathophysiology

1 Arterial Stiffness: A Simplified Overview in Vascular Medicine

19 Aging and Arterial Structure-Function Relations

Izzo, J.L. Jr. (Buffalo, N.Y.); Mitchell G.F. (Waltham, Mass.)

35 Local Elasticity Imaging of Vulnerable Atherosclerotic Coronary Plaques

Baldewsing, R.A.; Schaar, J.A.; Mastik, F. (Rotterdam); van der Steen, A.F.W. (Rotterdam/Utrecht)

62 Endothelial Function, Mechanical Stress and Atherosclerosis

76 Arterial Stiffness and Extracellular Matrix

96 Animal Models of Arterial Stiffness

Atkinson, J. (Nancy)

Section II - Arterial Stiffness, Atherosclerosis and End-Organ Damage

117 Blood Pressure, Large Arteries and Atherosclerosis

125 Arterial Stiffness and Coronary Ischemic Disease

139 Central Pulse Pressure and Atherosclerotic Alterations of Coronary Arteries

150 Does Brachial Pulse Pressure Predict Coronary Events?

160 Does Arterial Stiffness Predict Atherosclerotic Coronary Events?

McEniery, C.M. (Cambridge); Cockcroft, J.R. (Cardiff)

173 Carotid Atherosclerosis, Arterial Stiffness and Stroke Events

187 Atherosclerosis versus Arterial Stiffness in Advanced Renal Failure

Guerin, A.; Pannier, B.; London, G. (Fleury Merogis)

199 Arterial Stiffness and Peripheral Arterial Disease

Section III - Arterial Stiffness, Atherosclerosis and Cardiovascular Risk Factors

212 Cardiovascular Risk Factors, Atherosclerosis and Pulse Pressure

223 Pulse Pressure and Inflammatory Process in Atherosclerosis

234 Calcifications, Arterial Stiffness and Atherosclerosis

Mackey, R.H.; Venkitachalam, L.; Sutton-Tyrrell, K. (Pittsburgh, Pa.)

245 Diabetes and Arterial Stiffening

Winer, N. (New York, N.Y.); Sowers, J.R. (Columbia, Mo.)

252 Insulin Resistance, Arterial Stiffness and Wave Reflection

261 Cholesterol, Lipids and Arterial Stiffness

Wilkinson, I. (Cambridge); Cockcroft, J.R. (Cardiff)

278 Homocysteine and Large Arteries van Guldener, C. (Breda); Stehouwer, C.D.A. (Maastricht)

Section IV - Therapeutic Aspects

302 Nitrates, Arterial Function, Wave Reflections and Coronary Heart Disease

315 Modulation of Atherosclerosis, Blood Pressure and Arterial Elasticity by Statins

331 Atherosclerosis, Arterial Stiffness and Antihypertensive Drug Therapy

352 Author Index

353 Subject Index

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