ml/min/100 ml



CPBF/RCBF X10, arbitrary units



Values are mean ± 1 SEM. a p < 0.01; b p < 0.001; c p < 0.05.

Values are mean ± 1 SEM. a p < 0.01; b p < 0.001; c p < 0.05.

Intra-arterial determinations of brachial artery BP have been performed after 3 days' hospitalization in patients with PAD (aged between 30 and 70), compared with age- and sex-matched normal subjects [8, 9] (table 1). While DBP remains mostly maintained within the normal range, a significant and sustained increase of SBP was observed, resulting in a substantial elevation of pulse pressure (PP). This finding was observed even in PAD patients with the same mean arterial pressure (MAP) as normal subjects [8-10] (table 1). In the latter case, it was even shown that not only SBP was significantly increased but also that DBP was slightly reduced, thus contributing to the elevated PP [11]. However, it is worth noting that these hemodynamic abnormalities have been recorded at the brachial artery, a site where the PP is usually of higher amplitude than in the central aorta [12]. Although there is some reduction in amplification of the pulse with age, the age-related increase in PP in the central aorta can be considered as probably greater than is apparent from recordings of brachial artery BP [12], Thus, it seems likely that an elevated incidence of increased SBP and PP does exist in patients with PAD.

In patients with PAD, cardiac output and systemic vascular resistance remain largely within the normal range [8, 9]. Ventricular ejection, assessed from the ratio between stroke volume and left ventricular ejection time [8,

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