Chemotherapy in the HAART

In the HAART era, more recent standard chemotherapy regimens have been reported without excessive toxicity due to restored immunity.90 The AIDS Malignancy Consortium (AMC) reported using, in 65 patients, reduced doses of cyclophosphamide and doxorubicin, combined with vincristine and prednisone (modified CHOP, mCHOP) and full doses of CHOP combined with G-CSF with concomitant HAART. Complete response rates were 30 and 48 in the reduced-and full-dose groups, respectively.94 No long-term outcomes...

Impact of HAART on KS

Since the beginning of the AIDS epidemic in the early 1980s, AIDS KS has become one of the most common AIDS-associated malignancies with HIV-infected homosexual males at the highest risk, and those with AIDS had a 50 lifetime rate of developing KS early in the HIV epidemic.63 However, the rate of AIDS KS has since steadily declined both in the US and Europe.7 It has been suggested that the disease may have shifted from an early disease to a late manifestation during the HIV disease course....

Human Papillomavirus

HPV is a virus in the papovavirus family. It is a double-stranded DNA virus and generally infects stratified squamous epithelium, such as mucosal and squamous cells.274 The genome is approximately 8,000 bp in size, and based on genome sequence comparisons, over 100 HPV types have been identified to date. Approximately 30 of the known HPV types infect genital epithelium, and HPV is one of the most common sexually transmitted infections. Among HIV-infected individuals, human HPV infection has a...

List Of Contributors

Charles Wood, Ph.D, Nebraska Center for Virology, and the School of Biological Sciences, University of Nebraska, Lincoln, NE Anita Arora, MD, Center for Clinical Studies, Houston,TX Elizabeth Chiao, MD, Baylor College of Medicine, Houston,TX Stephen K.Tyring, MD, Ph.D, University of Texas Health Science Center, Houston, TX Whitney Greene, Tumor Virology Program, Children's Cancer Research Institute, Departments of Pediatrics, Microbiology and Immunology, and Molecular Medicine,The University of...