Clinical Presentation Of

Patients with MCD often have constitutional symptoms of fever and fatigue. On physical examination, diffuse lymphadenopathy, hepatosplenomegaly, and peripheral edema may be encountered. Further laboratory examination may reveal cytopenia, hypergammaglobulinemia, hypoalbuminemia, and raised C-reactive protein. Diagnosis of MCD is clinicopathological and thus based on lymph node biopsy with the clinical signs of a lymphoproliferative disorder and multisystem involve-ment.230,240 It has been suggested that HHV-8 load in the peripheral blood is the most accurate marker for monitoring MCD.149

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