Info

33 [18-40]

<50

Zidovudine IV, ganciclovir, IL-2; oral lamivudine; Indinavir

0.5, 4, 7, 22+, 13+*

3 patients received no HAART and 2 received AZT for <3 months

One patient received radiation, one responded but required another treatment (surviving 7 months), and one patient was lost to follow-up after treatment. (Adapted from reference 38)

One patient received radiation, one responded but required another treatment (surviving 7 months), and one patient was lost to follow-up after treatment. (Adapted from reference 38)

2—5.5 months compared to palliative care.35 McGowan and Shah43 were the first to describe a case of remission maintained for over 2 years in an individual who had PCNSL after treatment with HAART alone. Hoffmann and colleagues,44 in a retrospective analysis, showed that survival time of patients receiving HAART in addition to RT differed significantly from those receiving RT or palliative care alone. Four of the six patients receiving HAART survived for more than 1.5 years. Skiest and Crosby45 in a retrospective analysis demonstrated a prolonged median survival of 667 days in those individuals who did receive HAART.These findings are suggestive that immune recovery is contributing to longer remission in patients studied.

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