Antibodies to Nucleosomes Chromatin

Antibodies to nucleosomes have had a comeback in the last few years. This has to do with both the clinical utility of these antibodies in the diagnosis of SLE and drug-induced lupus DIL and new evidence suggesting that nucleosomes may be major candidate autoimmunogens in lupus. Since it is generally accepted that anti-nucleosome antibodies cause the LE cell phenomenon, they were actually among the first autoantibodies discovered. Of note, autoantibodies against individual components of...