Anticytosol Autoantibodies Type 1 antiLC1

Anti-LC-1 are viewed as a second marker of AIH type 2, in which they have been detected in up to 50% of LKM-positive sera [55]. Other studies indicate their occurrence in combination with ANA and SMA autoantibodies and in chronic HCV [56]. In contrast to LKM autoantibodies, LC-1 autoantibodies seem to correlate with disease activity. The molecular antigen target has been identified to be formiminotransferase cyclodeaminase and commercial kits have become available [57]. However, the specificity and clinical significance of these antibodies remain unclear.

296 13 Autoantibodies and Organ-specific Autoimmunity 13.5

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