Anti-LC-1 are viewed as a second marker of AIH type 2, in which they have been detected in up to 50% of LKM-positive sera . Other studies indicate their occurrence in combination with ANA and SMA autoantibodies and in chronic HCV . In contrast to LKM autoantibodies, LC-1 autoantibodies seem to correlate with disease activity. The molecular antigen target has been identified to be formiminotransferase cyclodeaminase and commercial kits have become available . However, the specificity and clinical significance of these antibodies remain unclear.
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