Autoantibodies and Organspecific Autoimmunity 291

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13.1 Role of Autoantibodies in Tissue-specific Organ Damage 291

13.2 Autoantibodies and Autoantigens in Autoimmune Hepatitis 292

13.3 Autoantibodies Frequently Associated with Autoimmune Hepatitis Type 1 292

13.3.1 Antinuclear Antibodies 293

13.3.2 Anti-Smooth Muscle Antibodies 293

13.3.3 Perinuclear Anti-neutrophil Cytoplasmic Antibodies (pANCAs) and Antibodies to Asialoglycoprotein Receptor (anti-ASGPRs) 294

13.4 Autoantibodies and Autoantigens Associated with Autoimmune Hepatitis Type 2 294

13.4.1 Liver Kidney Microsomal Antibodies 295

13.4.2 Anti-cytosol Autoantibodies Type 1 (anti-LC-1) 295

13.5 Autoantibodies and Autoantigens Associated with Autoimmune Hepatitis Type 3 296

13.6 Autoantibodies Associated with Primary Biliary Cirrhosis 296

13.7 Autoantibodies in Overlap Syndrome Between Autoimmune Hepatitis and Primary Biliary Cirrhosis 297

13.8 Discussion and Conclusions 297 References 299

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