Autoantibodies in Sjogrens Syndrome

SjS is a chronic inflammatory autoimmune disease of unknown origin characterized by lymphocytic infiltration into exocrine glands. Its primary symptoms are keratoconjunctivitis sicca and xerostomia, but several extraglandular manifestations may occur. There are two types of SjS: primary SjS and secondary SjS, which is associated with another underlying autoimmune disease. Ro/SS-A and La/SS-B antibodies are included in the classification criteria for SjS [29] and are detectable in 60-75% and 30-50% of patients, respectively. Anti-La/SS-B antibodies are mostly found in SjS and SLE patients. Therefore, La/SS-B antibodies in the absence of SLE-specific AABs are highly specific for SjS. If negative for Ro/La AAB, a-fodrin antibodies may be determined. The sensitivity and specificity of these AABs for SjS are lower than described earlier, however [30]. Some rarely detectable AABs (Coilin-p80, NuMA, Golgi apparatus antibodies) have no relevance for the diagnosis of SjS. AABs reacting with the M3 mus-carinic acetylcholine receptor (M3R) are described as highly sensitive and highly specific for SjS. Those AABs are probably involved in the pathogenesis of SjS [31, 32].

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