Cell Death

In addition to activation, T-B cell interactions may also result in cell death or apoptosis, generally of the B cell [72]. Such interactions typically involve death receptors such as CD95 (Fas), TNFR1 (TNF receptor-1), and the TRAIL receptors DR4 and DR5, whose dysfunction may lead to autoimmune manifestations, in part due to the inability to exclude autoreactive B cells from the lymphoid follicle and germinal center reaction [5, 73, 74]. However, a detailed description of cell death and apoptosis in autoimmunity is beyond the scope of this chapter, and the reader is directed to other sections of this book for further details (e.g., see Chapters 4 and 6).

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