Two of the 10 patients dropped out of the trial due to complications other than MTX toxicity. After 4 years of the trial, CSF IL-6 levels were significantly decreased (Fig. 1). The neuropsychiatric manifestations as well as the findings on MRI scans and intelligence quotients were not significantly worsened (Fig. 2). Three patients presented with mild liver dysfunction, which returned to normal by decreasing the doses of MTX or supplementing folate (5.0 mg-10 mg/week).
Figure I. Cerebrospinal fluid (CSF) IL-6 in patients with progressive NB: Normal range for CSF IL-6 is below 0.05 (J/ml (10 pg/ml). Solid circle indicates the point of drop out. Statistical analysis was done by Wilcoxon signed test.
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