Some examples of fundus images with nonuniform illumination. Note in the rightmost image how the lower portion of the image is blurred.

online operation do not have this luxury. They must be able to work with image frames with suboptimal illumination, and be able to detect when image quality is too poor for processing, and then reject these frames. They must not only be adaptive enough to be useful and reliable, but also efficient enough to handle high data rates. While much work remains to be done in this area, much progress has been made. Some of the algorithms described in Section 6.5 were designed in the context of such conflicting, practical, and extreme needs.

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