Dehydroepiandrosterone (DHEA) is a major circulating steroid and is clinically useful for treatment of diseases in mammals. Rainbow trout fed DHEA for 30 weeks developed hepatic neoplasms, and there was also an enhancement of MNNG (Orner et al., 1996) and AFBrinitiated carcinogenicity (Orner et al., 1995). Daily doses lower than used in human clinical trials were carcinogenic in rainbow trout. Carcinogenicity of DHEA in rainbow trout appeared to be the result of genotoxicity and was independent of peroxisome proliferation.

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