Cardiac Cells

Both rat cardiac myocyte and fibroblast actively secrete AM. AM secretion rate from neonatal cardiac myocyte was determined by 3 groups to be 0.92, 0.96 and 0.40 fmol/105 cells/h, while that from neonatal cardiac fibroblast to be 2.57, 0.51 and 0.50 fmol/105 cells/h (Tomoda, 2001a; Horio, 1998; Tsuruda, 1998, 1999). The regulation profile of AM secretion from cardiac fibroblast is the typical one of the fibroblast, and angiotensin II and endothelin-1 increased AM secretion rates about 1.5 fold (Tsuruda, 1999).

Table 2. Effects of various substances on AM secretion from rat cardiac myocyte and fibroblast.

Substance

Myocyte

Fibroblast

TNF-a

—

t.ttt(t)

IL-lß

— t(t)

tt.ttt(t)

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