African green monkey kidney cells

Continuous line of cells used for growth of certain viruses of vertebrates including adenoviruses, SV40, rotaviruses, Poliovirus, Rubella, arboviruses and paramyxoviruses such as Measles virus. There are three commonly used lines: BSC-1, CV-1 and Vero cells.

African green monkey polyomavirus (AGMPyV) A species in the genus Polyomavirus. Isolated from a South African vervet monkey kidney cell culture. Has been adapted to growth in primary rhesus monkey kidney cell cultures. Virion diameter is 40-45nm. The superhelical, circular double-stranded DNA has a mean length 101% of the length of SV40 DNA (5.2kb). Has the internal capsid antigen common to all papovaviruses of the SV40 polyoma group. Unrelated to other papovaviruses by neutralization tests. T antigen is indistinguishable from the T antigen of SV40. Transforms hamster kidney cells. Natural host probably the chacma baboon, Papio ursinus.

Synonym: B-lymphotropic papovavirus strain K38.

Valis JD et al (1977) Infect Immun 18, 247

African horse plague virus Synonym for African horse sickness virus.

African horse sickness virus (AHSV) A

species in the genus Orbivirus with 9 serotypes.

African horse sickness viruses 1-9 (AHSV1-9) Serotypes in the genus Orbivirus. There are nine serotypes identified by neutralization tests. There is a group-specific CF antigen. Only equids and dogs are naturally susceptible. Causes disease which may be fatal in horses, mules and donkeys. Dogs, elephants and zebras are possible reservoir hosts. In severe cases death occurs from pulmonary edema. In chronic cases there is cardiac involvement with edema of the head and neck. Some infections are mild.

Viremia often occurs. Transmitted by nocturnal biting flies of the genus Culicoides. Experimentally goats are slightly susceptible but ferrets and dogs are infected more readily. Mice, rats and guinea pigs can be infected i.c. A mouse brain passage virus vaccine is effective. Virion is 75-80nm in diameter, icosahedral and similar to Bluetongue virus. Infectivity is ether-resistant but acid-sensitive, being inactivated below pH 6. Horse erythrocytes are agglutinated. Virus contains double-stranded RNA in 10 segments. Multiplies in eggs in yolk-sac, and in cell cultures of many species. Although originally confined to Africa, the virus was inadvertently introduced into Spain, and is now endemic around Madrid and other areas to the south. Synonyms: African horse plague virus; perdesiekte virus; pestis equorum virus.

Mellor PS (1994) Comp Immun Microbiol Infect Dis 17, 287

Mertens PPC (1999) In Encyclopedia of Virology, Second edition, edited by A Granoff and RG Webster. London: Academic Press, p. 1043

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