ARDS See acute respiratory distress syndrome

Arenaviridae (Latin: arenosus = sandy) A family of RNA viruses 50-300nm in diameter (usually 110-130nm), spherical or pleomorphic. They have a dense lipid bilayer membrane covered with projections, surrounding a core which contains ribosome-like particles. Virion proteins include two glycopeptides and two polypeptides. Genome consists of two species of single-stranded RNA with mol. wt. of 2.3 x 106 and 1.2 x 106 called L and S segments. Viral RNA is transcribed by a virion polymerase into complementary RNA which acts as mRNA. Both the L and S segments are ambisense. The L segment encodes a large polymerase protein,

L, in negative sense, and a small zinc-binding protein, Z, in plus sense. The S segment encodes a nucleocapsid, N protein in negative sense, and a glycoprotein, GPC, in plus sense. Virus is synthesized in the cytoplasm and matures by budding through the cell membrane. Infectivity sensitive to lipid solvents. There are two genera: Arenavirus and Deltavirus. The name was at first spelt arenovirus (arenosus = sandy) but this was altered to avoid confusion with the adenoviruses.

Bishop DHL and Auperin DD (1987) Curr Top Microbiol Immun 133, 5

Salvato MS (editor) (1993) The Arenaviridae. New York: Plenum Press

Arenavirus A genus in the family Arenaviridae. The type species is Lymphocytic choriomeningitis virus. All species are antigenically related but can be divided into two phylogenetic and serological groups: (1) the Old World Arenaviruses, e.g. Lassa virus and Lymphocytic choriomeningitis virus; (2) New World Arenaviruses, e.g. the Tacaribe antigenic group viruses. Most species have a single rodent or bat host in which they cause a persistent infection with viremia and/or viruria.

Bowen MD et al (2000) J Virol 74, 6992 Wulff H et al (1978) Intervirology 9, 344

Argentina virus Synonym for the Indiana 2A strain of Vesicular stomatitis virus.

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