B

B cells Lymphocytes derived from hemo-poietic stem cells in the bone marrow (or the bursa of Fabricius in birds) which synthesize immunoglobulin and play a major role in the adaptive immune response.

B14-150 cells (CCL 14.1) Heteroploid peritoneal cells from the Chinese hamster, Cricetulus griseus. Initiated from the original B14 cell line by selection of cells resistant to bromo-deoxyuridine in the culture medium. This was later replaced by idoxuridine to which the cells are now resistant.

B95-8 cells An Epstein-Barr virus transformed marmoset B-lymphocyte cell line. Used for primary measles virus isolation.

Kobune F et al (1990) J Virol 64, 700

B-virus Synonym for Cercopithecine her-pesvirus 1 (herpesvirus B).

B19 virus (B19V) A species in the genus Erythrovirus, the cause of erythema infec-tiosum (fifth disease) in children and of aplastic crisis in children and adults with chronic hemolytic anemia. The linear single-stranded DNA genome of B19 virus is 5.5kb in length and has long (about 300 bases) inverted terminal repeats at the 3' and 5' ends. Both plus and minus strands are packaged with equal efficiency into B19 virions. Human B19 infection is common between ages 4 and 12 years but is usually asymptomatic; serosurveys have shown that about 80% of the adult population have experienced B19 infection. Erythema infectiosum is a common manifestation of childhood infection and starts with intense erythema of the cheeks (slapped-cheek disease), then moves to the trunk and limbs, lasting about 2 days. In a few cases (< 10%) arthropathy with joint symptoms is seen, but when infection occurs in adult females, 80% of cases have associated arthropathy. B19 virus infects erythrocyte precursors, and if the infected individual has pre-existing hemolytic anemia a transient aplastic crisis occurs which usually lasts for 7 days, before a humoral immune response is mounted. More serious, chronic anemia occurs in immunocompromised individuals. In pregnant women, intrauterine B19 infection may cause fetal loss and hydrops fetalis.

Anderson LJ and Young NS (1997) Monogr Virol 20, 153 pp.

Berns KI (1990) Microbiol Rev 54, 316 Erdman DD et al (1996) J Gen Virol 77, 2767

734 B virus A possible species in the genus Betaretrovirus. Present in MCF-7 cells, a line derived from a pleural effusion from a patient with disseminated mammary adenocarcinoma. No antigenic relationship with type C retroviruses, but some cross-reaction with Mouse mammary tumor virus.

B814 virus The first strain of Human coron-avirus isolated in organ culture from a patient with a common cold.

Tyrrell DAJ and Bynoe ML (1965) BMJ 1, 1467

B-virus of monkeys Synonym for

Cercopithecine herpesvirus 1.

Babahoya virus (BABV) A serotype of Patois virus in the genus Bunyavirus belonging to the Patois serogroup. Isolated from mosquitoes, Culex (Melanoconion) ocossa, in Ecuador. Not known to cause disease in humans.

Calisher C et al (1983) Am J Trop Med Hyg 32, 877

Babanki virus (BBKV) A serotype of Sindbis virus in the genus Alphavirus. Isolated from the mosquito, Mansonia africana, in Cameroon.

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