Canine adenoviruses 1 and 2 CAdV1 and

-2) Two serotypes of Canine adenovirus, a species in the genus Mastadenovirus. A natural infection of dogs, often silent, but in puppies there is often fever, vomiting and diarrhea with up to 25% mortality. There is cutaneous edema, ascites, hemorrhages into the viscera and hepatitis. Also a cause of laryngotracheitis (kennel cough). In foxes there is acute encephalitis and hemorrhage into the brain. Spread of infection is from the respiratory tract and urine. Experimentally, dogs and foxes may be infected by any route. Bears, coyotes, wolves and raccoons are susceptible. Virus replication with CPE occurs in cultures of dog, ferret, raccoon and pig cells. Hemagglutination is reported. A modified live vaccine, attenuated by passage in pig kidney cell cultures, produces solid immunity following a single dose in dogs of any age. The complete DNA sequence of canine adenovirus 1 has been determined. There was little identity to human adenoviruses in the early region genes, more in the late genes. Sequences of the early region (E3) genes showed distinct sequences in canine adenovirus 2 as compared to canine adenovirus 1. Synonyms: canine hepatitis virus; canine laryngotracheitis virus; fox encephalitis virus; hepatitis infectiosa canis virus; infectious canine hepatitis virus; Rubarth's disease virus.

Koptopoulos G and Cornwell HJC (1981) Vet

Bull, Lond 51, 135

Linne T (1992) Virus Res 23, 119

Morrison MD et al (1997) J Gen Virol 78, 873

canine calicivirus (CaCV) An unassigned species in the family Caliciviridae. Isolated from the feces of a dog with diarrhea, and propagated in canine kidney cells and in a dolphin cell line.

Schaffer FL et al (1985) Arch Virol 84, 181

Canine coronavirus (CCoV) A species in the genus Coronavirus. Causes vomiting and diarrhea in dogs. Antigenically related to feline infectious peritonitis virus and to porcine Transmissible gastroenteritis virus, which can be transmitted to dogs, but only CCoV causes disease. Replicates in a variety of canine and feline cell lines. Fecal material is the main source of infection, and disease can be prevented by avoiding contact with infected dogs and their excretions.

Synonym: gastroenteritis virus of dogs.

Cartwright S and Lucas M (1972) Vet Res 91, 571

Pratelli A et al (2000) J Virol Meth 84, 91 Tennant BJ et al (1993) Vet Rec 132, 7

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