Central nervous system viral infections

Many viruses such as rabies, measles, mumps and herpes simplex may infect the nervous system and cause serious disease. Viruses may enter the nervous system along nerves and through the blood. Once in the central nervous system viruses may cause acute or slow chronic infections.

Johnson RT (1999) In Encyclopedia of Virology, Second edition, edited by A Granoff and RG Webster. London: Academic Press, p. 1013

centrifugation-enhanced culture Detection of a cytopathic effect in a culture of cells may require days or weeks. For some viruses this process can be speeded up by centrifuging the culture.

Faisst S (1999) In Encyclopedia of Virology, Second edition, edited by A Granoff and RG Webster. London: Academic Press, p. 1408

centrophyten Minute basophilic particles reported by Lipsch├╝tz (1928, Wien Klin Wschr 41, 365) to be present in epidermal cells infected with Measles virus.

Cercopithecine herpesvirus 1 (CeHV-1)

Cercopithecine herpesvirus 1 (CeHV-1) A

species in the family Herpesviridae. A natural infection of Asiatic macaque monkeys. 10% of newly caught rhesus monkeys have antibodies, and the virus is frequently present in kidney cell cultures of this animal. Reservoir species include Macaca mulatta, M. fascicularis, M. fuscata, M. arctoides, M. cyclopsis and M. radiata. Causes vesicular lesions on the tongue and lips, and sometimes of the skin. Infection of humans by monkey bites or other means leads to ascending myelitis or acute encephalitis; almost all cases are fatal. Mice under 3 weeks old, day-old chicks and guinea pigs can be infected experimentally. Not all strains are antigenically identical.

Synonyms: B-virus of monkeys; her-pesvirus simiae.

Holmes GP et al (1995) Clin Infect Dis 20, 421 Ludwig H et al (1983) In The Herpesviruses, vol. 2, edited by B Roizman. New York: Plenum Press, p. 385

Smith AL et al (1998) J Virol 72, 9224

Cercopithecine herpesvirus 2 (CeHV-2) A

species in the genus Simplexvirus. Isolated from vervet monkey, Cercopithecus aethiops, kidney cultures. Genome DNA is 67% G+C. Partial genome sequences of several genes are related to their homologs in herpes simplex virus. Infectivity is neutralized by antisera to herpesvirus B (Cercopithecine herpesvirus 1). Synonym: SA8 virus.

Eberle R et al (1993) Arch Virol 130, 391 Hilliard J et al (1989) Arch Virol 109, 83

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