Congenital varicella syndrome CVS A

severe disease of the fetus resulting from maternal infection with Human her-pesvirus 3 during the first two trimesters of pregnancy. Clinical manifestations range from multisystem involvement resulting in death in the neonatal period to dermatomal skin scarring, limb hypoplasia, or both as the only defects. The disease is rare and the overall risk of zoster in infancy following maternal varicella infection in the second and third trimesters of pregnancy is about 2%.

da Silva O et al (1990) Pediatr Inf Dis J 9, 854

conglutinin A protein in the collectin family that acts as a first line of defense against infectious agents.

Epstein J et al (1996) Curr Opinion Immunol 8,29

Congo virus See Crimean-Congo hemor-rhagic fever virus.

conjunctival infection The most common conjunctival infections are associated with adenovirus, coxsackie virus A24, and enterovirus 70, and the conjunctiva may represent a primary portal of entry for these viruses.

Yin-Murphy M (1984) Prog Med Virol 29,23

Connecticut virus (CNTV) An unassigned species in the family Rhabdoviridae, belonging to the Sawgrass serogroup. Isolated from ticks Ixodes dentatus in Connecticut, USA.

consensus sequence A short nucleotide sequence in which each position represents the base most often found when many actual sequences of a genetic element are compared. For example, consensus sequences are found at the exon-intron junction in DNA, at preferred splice junctions in RNA, and at ribosomal binding sites involving translation initiation (see Kozak sequence).

conservative replication A model for nucleic acid replication which does not occur in nature. The original or parent double strand is preserved intact and the progeny molecule has both strands newly synthesized. In nature a semi-conservative method takes place.

contact infection A disease transmitted by close mechanical contact between organisms, e.g. common cold or herpes.

contact inhibition When normal cells come into contact their movements cease. Cell division is also inhibited, but since this is dependent on other factors as well, the term 'contact inhibition' is used to imply loss of movement only. See density-dependent inhibition.

Abercrombie M (1979) Nature 281, 259

contagious ecthyma virus Synonym for chamois contagious ecthyma virus.

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