Diseases caused by cytomegalovirus infection are marked by characteristic large refractile inclusion bodies (known as 'owl eye' inclusions).These are found in patients suffering from classical congenital CMV infection, and also in AIDS patients suffering from CMV, a frequent opportunistic infection.
Cytomegalovirus One of three genera in the subfamily Betaherpesvirinae, containing three species, Human herpesvirus 5 (human cytomegalovirus), Cercopithecine herpesvirus 5 and Cercopithecine herpesvirus 8. Tentative species in the genus are aotine herpesvirus 1 and aotine her-pesvirus 3. The members of the genus are grouped on the basis of the nucleotide sequence similarity of their genome DNAs.
cytomegalovirus group Synonym for Betaherpesvirinae.
cytopathic effect (CPE) Alteration in the microscopic appearance of cells in culture following infection with a virus. May consist of rounding up, cell detachment, cell fusion, production of inclusion bodies, etc. Neutralization of CPE is widely used in serological identification of viruses.
cytoplasmic amphibian viruses Synonym for icosahedral cytoplasmic deoxyviruses of amphibians.
cytoplast An enucleated eukaryotic cell. Used to study dependence of virus replication on the cell nucleus.
Cytorhabdovirus A genus of plant rhab-doviruses. The type species is Lettuce necrotic yellow S virus.
cytoryctes variolae The name originally applied by Guarnieri to the inclusion bodies which now take his name, who was under the impression that they were protozoa.
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