Far East Russian encephalitis virus

Synonym for tick-borne encephalitis virus (Far Eastern subtype).

farnesylation The addition of three iso-prene units (farnesyl group) to a protein. The farnesyl group is specifically attached to proteins that have the C-ter-minal motif CAAX, and is believed to play a role in membrane attachment. This modification is essential for virion formation of Hepatitis delta virus.

Otto JC and Casey PJ (1996) J Biol Chem 271, 4659

fatal familial insomnia See prion diseases.

fat head minnow cells See FHM cells.

FBJ osteosarcoma virus See Finkel-Biskis-Jinkins murine sarcoma virus.

Fc fragment The crystallizable fragment of the immunoglobulin molecule that is obtained following treatment with papain. Contains portions of two heavy chains and no antigen-binding sites.

Fc receptor A cell surface component which binds to the Fc portion of immunoglobu-lin molecules.

Fc2Lu cells (CCL 217) A cell line derived from normal lung tissue of a near full-term male cat fetus.

Fc3Tg cells (CCL 176) A cell line, established from normal embryonal tongue tissue of a female cat, which is susceptible to a wide variety of known feline viruses.

Felid herpesvirus 1 (FeHV-1) A species in the genus Varicellovirus. Cats which have recovered from infection with this virus may still carry it and infect kittens, in which it causes nasal discharge, lacrima-tion and fever. Virus replicates in the mucous membranes of the nose, larynx and trachea, also in the conjunctiva, and can infect the genital tract. In cats older than 6 months, the disease is mild or sub-clinical, though pregnant queens may abort. Causes similar clinical disease in wild felids such as cheetahs in captivity. Focal lesions are produced in cell cultures from cat kidney, lung and testis. There is no CPE in cultures of bovine, human or monkey cells.

Synonyms: feline herpesvirus 1; feline rhinotracheitis virus.

Gaskell R and Willoughby K (1999) Vet Microbiol 69, 73

van Vuuren M et al (1999) J S Afr Vet Assoc 70, 132

felid herpesvirus 2 (FeHV-2) Probably a strain of Bovine herpesvirus 4 in the genus Rhadinovirus. A cell-associated her-pesvirus isolated during studies of feline urologic syndrome. Induced formation of syncytia, and nuclear inclusions which were found to contain herpes virions by electron microscopy. Intracellular and extracellular crystals were formed, some of which were identified as cholesterol. More recent restriction endonuclease and fluorescent antibody analyses indicate a close relationship of the feline cell-associated virus to Bovine herpesvirus 4.

Fabricant CC and Gillespie JH (1974) Infect Immun 9, 460

Gaskell RM et al (1979) Vet Rec 105, 243 Kruger JM et al (1990) Am J Vet Res 51, 879

feline agranulocytosis virus Synonym for Feline panleukopenia virus.

Feline astrovirus (FAstV) A species in the genus Astrovirus. Only one serotype has been detected.

feline astrovirus 1 (FAst-V-1) A serotype of Feline astrovirus.

Feline calicivirus (FCV) A species in the genus Vesivirus. Several serotypes are described. Most strains have been isolated from the respiratory tract but some may be associated with the gastrointestinal tract. Experimental exposure to aerosol of virus caused rhinitis, conjunctivitis, oral ulceration and pneumonia. Infection most often seen in catteries, may be mild or severe, even fatal. Replicates in cultures of feline cells more readily than rhi-novirus. An attenuated strain is used as a vaccine, given intranasally or i.m. Synonyms: cat flu virus.

Carter MJ et al (1992) Virology 190, 443

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