Feline cellassociated herpesvirus FCAHV

A strain of Bovine herpesvirus 4. See also felid herpesvirus 2.

Feline coronavirus (FcoV) A species in the genus Coronavirus. Antigenically related to porcine Transmissible gastroenteritis virus but infection with Transmissible gastroenteritis virus does not give immunity to infectious peritonitis. Cats of any age, leopards and other large cats are susceptible. Causes a gradual loss of appetite, wasting and abdominal distension due to fibrinous peritonitis. Fatal in a few weeks. There is often pleurisy and necrotic inflammatory lesions in many organs. Infective virus is present in ascitic fluid and organ extracts. There is hypogammaglobulinemia and there may be meningo-encephalitis and panoph-thalmitis. Recombinants, known as type II strains, have been found naturally which arose by recombination with Canine coronavirus.

Synonym: Feline infectious peritonitis virus.

Horzinek MC and Osterhaus ADME (1979)

Arch Virol 59, 1

Lai MMC and Cavanagh D (1997) Adv Virus Res 48,1

feline endogenous retrovirus There are at least three groups of endogenous feline retroviruses. One is represented by an endogenous cat type C retrovirus obtained from a continuous cat cell line CCC. It does not have the group-specific antigen of the exogenous cat leukemia virus but does have that of RD 114 virus. RD 114-related nucleic acid sequences are found at about one complete copy per cell in the six Felis species of the family Felidae, although they are also present in Old World monkeys and apes (see baboon endogenous virus). It is a xenotropic virus, which can be induced by treatment of CCC cells with idoxuri-dine. The second group, endogenous feline leukemia viruses, is very similar to exogenous feline leukemia viruses, and probably represents multiple integrations of the exogenous virus. The main difference between the endogenous and exogenous viruses is in the U3 region of the LTR. These endogenous viruses have not been isolated, but are detectable because of their recombination with exogenous viruses. The third group, represented by a newly described virus, FcEV (Felis catus endogenous retrovirus), is a type C virus present at 15-20 copies per cell, which probably gave rise to RD 114 virus by recombination with a baboon endogenous retrovirus, from which it acquired the env gene.

Sheets RL at al (1993) J Virol 67, 3118 van der Kuyl AC et al (1999) J Virol 73, 7994

feline enteritis virus Synonym for Feline panleukopenia virus.

Feline foamy virus (FFV) A species in the genus Spumavirus. Has been isolated from normal cats and from cats with various diseases in at least three continents. There are two serotypes. Not known to cause disease. Replicates in feline embryo cell cultures. Infected cells contain infectious proviral DNA of mol. wt. 6 x 106. Late in the course of infection, the provirus is integrated into the host cell genome.

Synonym: Feline syncytial virus.

Chiswell DJ and Pringle CR (1979) J Gen Virol 44, 145

feline herpesvirus 1 Synonym for Felid her-pesvirus 1.

Feline immunodeficiency virus (Petuluma)

(FIV-P) A species in the genus Lentivirus, isolated in 1987 from cats with AIDS-like illness (feline AIDS). Probably an endemic infection of domestic cats throughout the world. Similar viruses have been isolated from wild felids (e.g. lion, puma, Tsushima cat) in Africa, Japan and North America but are not known to cause disease in their host species. The virus is present in saliva of infected cats and transmitted by bites. Venereal transmission has not been demonstrated. The virus infects cells of the monocyte-macrophage system and 4-8 weeks after infection causes a primary mononucleosis-like disease with fever and leukopenia, usually followed by recovery. This primary disease may be more severe in cats that are co-infected with Feline leukemia virus. It is followed by a gradual decline in CD4+ T-cell counts over a period of months to years until the immune system fails. Antibodies to several virion proteins appear in the first few weeks after infection and can be used in ELISA, IFA or Western blot tests to diagnose infection. In vitro, the virus grows in CD4+ or CD8+ primary T-lymphoblast cells as well as peritoneal macrophages. As with HIV, there appear to be many genetic variants which may coexist even in a single host, and have different growth properties on various cell lines. Five main subtypes, A-E, are recognized by sequence analysis of the viral env and gag genes. Provides a useful model for AIDS studies.

Bendinelli M et al (1995) Clin Microbiol Rev 8, 87 Elder JH and Phillips TR (1995) Adv Virus Res 45, 225

Nishimura Y et al (1998) Virus Res 57, 101 Yamamoto JK et al (1999) In Encyclopedia of Virology, Second edition, edited by A Granoff and RG Webster. London: Academic Press, p. 535

Feline immunodeficiency virus - Oma (FIV-

O) A species in the genus Lentivirus, isolated in 1995 from a captive Pallas' cat, Otocolobus manul, in the USA. A highly cytopathic virus which shares a major core protein antigen with FIV-P, but differs more than 20% in sequence homology based on the pol gene.

Barr MC et al (1995) J Virol 69, 7371

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