Feline infectious peritonitis virus FIPV

Synonym for Feline coronavirus.

Feline leukemia virus (FeLV) A species in the genus Gammaretrovirus. A common infection of cats causing leukemia and/or sarcomas. Depresses immune system leading to a variety of opportunistic infections. Virus replicates in cells of feline, human, canine and pig origin. The viruses replicate in feline fibroblast cells in vitro and are classified into subgroup A, B or C according to their interference patterns in vitro. Subgroup A viruses are restricted to growth in feline cells, whereas subgroup B and C viruses will also grow in canine, human or mink cells. Replication is not cytopathic and virus can be propagated for long periods in feline fibroblast cells. Persistently infected cats shed virus in saliva, urine and feces and young kittens are easily infected up to 4 months old. A majority of infected cats shed virus for up to 3 months before developing neutralizing antibody, but up to 5% of cats remain persistently infected and shed virus for a few years before disease develops. Over 80% of these persistently infected cats will die within 3-4 years. Commonly, the disease involves a T-cell lymphosarcoma or thymic atrophy leading to immunosup-

pression and consequent degenerative diseases. Feline leukemia viruses frequently undergo recombination with host cell genes and yield replication-defective recombinant feline sarcoma viruses in which one of at least seven cellular oncogenes has been transduced by FeLV.

Feline sarcoma virus isolates and their respective host oncogenes are:

Gardner-Arnstein GA-FeSV (c-fes) Gardner-Rasheed GR-FeSV (c-fgr) Hardy-Zuckerman HZ1-FeSV (c-fes) Hardy-Zuckerman HZ2-FeSV (c-abl) Hardy-Zuckerman HZ4-FeSV (c-kit) Hardy-Zuckerman HZ5-FeSV (c-fms) Noronha-Youngren NY-FeSV (c-ki-ras) Parodi-Irgens PI-FeSV (c-sis) Snyder-Theilen ST-FeSV (c-fes) Susan-McDonough SM-FeSV (c-fms) Theilen-Pedersen TP1-FeSV (c-fgr) Synonyms: cat type C oncovirus; feline sarcoma virus.

Hardy WD (1993) In The Retroviridae, vol. 2, edited by JA Levy. New York: Plenum Press, p. 109

Rohn JL et al (1996) Leukemia 10, 1867

Neil J and Onions D (1999) In Encyclopedia of

Virology, Second edition, edited by A Granoff and RG Webster. London: Academic Press, p.

Feline panleukopenia virus (FPLV) A

species in the genus Parvovirus. A natural infection of felids (domestic cats, lions and tigers), but in zoos usually the smaller species (raccoons, mink and foxes) are susceptible. Chiefly seen as a severe febrile illness, with vomiting and sometimes blood-stained diarrhea in young cats, although older cats may be attacked when virus is first introduced to a previously virus-free group. Subclinical and mild cases probably occur and give immunity. Infected animals may excrete virus for a year, and virus contaminating the environment may remain infectious for months. Kittens infected before 9 days of age may suffer damage to the developing cerebellum and at 3-4 weeks show ataxia and tremors. Cats, mink and newborn ferrets can be infected experimentally. After an initial leukocytosis there is a progressive fall in circulating lymphocytes and polymorphs, with lethargy and anorexia. Virus replicates in kitten kidney cell cultures. CPE may be transient. Virus replicates best in rapidly dividing cells. Some strains have weak hemagglutinins which bind to pig erythrocytes at 4°C. An attenuated virus vaccine gives protection. Synonyms: ataxia of cats virus; cat distemper virus; cat fever virus; cat plague virus; enteritis of mink virus; feline agranulocytosis virus; feline enteritis virus; feline infectious aleukocytosis virus; feline infectious enteritis virus; Feline parvovirus; show fever virus.

Parrish CR (1990) Adv Virus Res 38, 403 Parrish CR (1999) In Encyclopedia of Virology, Second edition, edited by A Granoff and RG Webster. London: Academic Press, p. 1159

Feline parvovirus (FPV) A species in the genus Parvovirus.

feline pneumonitis virus Not a virus. A species of chlamydia (Chlamydia psittaci).

feline respiratory viruses The clinical picture of acute upper respiratory disease in the domestic cat may be caused by a number of different viruses, Felid herpesvirus 1, Feline calicivirus and Feline panleukopenia virus, and by feline pneu-monitis agent, which is a chlamydia.

feline rhinotracheitis virus Synonym for Felid herpesvirus 1.

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