Fetal rhesus kidney virus Synonym for

Bovine polyomavirus.

a-fetoprotein (AFP) A protein present in the serum of vertebrate embryos. Presence in the amniotic fluid is diagnostic for spina bifida in the human fetus. Serum levels of AFP are normally less than 20 ng/ml, but may rise above 1000 ng/ml when hepatocellular carcinoma (frequently associated with Hepatitis B or C virus infection) is present.

Feulgen stain One of the few staining methods specific for DNA.

FHM cells (CCL 42) A heteroploid cell line derived from tissue posterior to the anus, exclusive of the caudal fin, of normal adult fat head minnows, Pimephales promelas, of both sexes. Supports growth of Infectious pancreatic necrosis virus, frog virus 1 and some other fish viruses.

FHs 74 Int cells (CCL 241) A cell line established from the small intestine of an apparently normal, 3- to 4-month-old human female fetus.

Fialuridine A pyrimidine analog (2-fluoro-5-iodoarabinofuranosyluracil) used as a potential therapy for hepatitis B infection. Withdrawn because of multi-organ toxic-ity with several fatalities during early clinical trials. Synonym: FIAU.

Colacino JM (1996) Antiviral Res 29, 125

Finkel-Biskis-Jinkins murine sarcoma virus (FBJMSV)

fibroblasts Cells derived from connective tissue that secrete fibrillar procollagen, fibronectin and collagenase.

fibroma virus See under host animal species, e.g. Rabbit fibroma virus.

fiebre amarilla virus Synonym for Yellow fever virus.

field mouse herpesvirus Synonym for murid herpesvirus 5.

fievre typhoide du cheval virus Synonym for Equine arteritis virus.

fifth disease Erythema infectiosum, which was the fifth disease in a classification of six erythematous rash illnesses of children. Results from infection of young children with the parvovirus B19. See Erythema infectiosum.

filipin A polyene antibiotic which interacts with sterols in liposomes and biological membranes, producing alterations in the lipid bilayer structure. Exposure of Vesicular stomatitis virus to the drug led to a change in the permeability barrier of the virus envelope.

Filoviridae A family consisting of a single genus Filovirus, containing two genera, 'Marburg-like viruses' and 'Ebola-like viruses'. Both Marburg and Ebola viruses cause severe hemorrhagic fevers in humans and other primates, with extremely high mortality (up to 90%). Marburg virus so far appears to be a single virus type, whereas four subtypes of Ebola virus have been recognized: Zaire, Sudan, Reston and Côte d'Ivoire. Except for their extreme length, the viruses have a morphology somewhat similar to that of members of the family Rhabdoviridae. They are filamentous, with U-shaped, 6-shaped or circular forms produced in cell culture. The length is highly variable and can be as great as 14000 nm but it is usually about 800-1000 nm; the diameter is 80 nm. The particles are enveloped with spikes ca. 7 nm in length and 10nm apart. The virus RNA is 19.1 kb in length, negative-sense and is therefore non-infectious. There are at least seven virus proteins with mol. wt. of ca. 267 (RNA

transcriptase-polymerase), 75 (surface glycoprotein), 78 (nucleoprotein), 32 (matrix), 31 (P protein), 32 (minor nucleo-protein) and 29 (second matrix protein). Both viruses are highly virulent for humans and several species of monkey. Despite numerous field investigations, the presumed reservoir from which filovirus infections originate has not been found.

Feldmann H and Klenk H-D (1996) Adv Virus Res 24,1

Klenk H-D (editor) (1999) Marburg and Ebola Viruses. Curr Tops Microbiol Immunol 235, 225pp Peters CJ et al (1994) Semin Virol 5, 147

Filovirus See Filoviridae.

finch paramyxovirus See Avian paramyxovirus 2.

fingerprinting A procedure for characterizing DNA, RNA or proteins by electrophoretic or chromatographic analysis of specific fragments, e.g. uniformly or terminally labeled RNA is digested using various ribonucleases (often T1 or pancreatic) and the products separated by electrophoresis in two dimensions. The oligoribonucleotides are then detected by autoradiography.

Finkel-Biskis-Jinkins murine sarcoma virus (FBJMSV) A species in the genus Gammaretrovirus. A naturally occurring mouse sarcoma virus species (MSV). Isolated from a spontaneous osteosar-coma in the thoracic spine of a CFl mouse. Induces perosteal sarcomas in mice after a short latent period (3 weeks). In cell cultures produces foci of altered cells, different in morphology from those produced by other strains of mouse sarcoma virus. It is accompanied by a helper leukemia virus. Unlike other strains of MSV, it transforms mouse embryo cells into autonomously replicating cells; it thus produces plaques without having to produce infective virus. Produces osteosarcomas on injection into newborn Syrian hamsters. Carries the transduced fos (finkel osteogenic sarcoma) oncogene, which encodes a nuclear DNA-binding protein.

Finkel MP and Biskis BO (1968) Prog Exp

Tumor Res 10, 72

fin V707 virus (FINV)

fin V707 virus (FINV) A strain of

Uukuniemi virus in the genus Phlebovirus. Isolated from five male ticks, Ixodes uriae, from a murre colony at Vedoy Rost Islands, Lofoten, Norway in 1975. Synonym: NorV-707.

Saikku P et al (1980) J Med Entomol 17, 360

fishpox virus Synonym for cyprinid herpesvirus 1.

fish viruses Viruses that affect fish occur in many virus families. In addition, a number of viruses have been isolated from fish with no known disease association. Here, the main disease-causing viruses are listed; further details may be found under the individual entry for each virus.

Agents of moderate to high virulence: angelfish reovirus (Reoviridae) Barfin flounder nervous necrosis virus (Nodaviridae)

cichlid virus (Rhabdoviridae) Dicentrarchus labrax encephalitis virus (Nodaviridae)

eel virus European (Birnaviridae) erythrocytic inclusion body syndrome (Togaviridae)

esocid lymphosarcoma virus (Retroviridae)

grass carp reovirus (Reoviridae) herpesvirus salmonis (Herpesviridae) Hirame rhabdovirus (Rhabdoviridae) Ictalurid herpesvirus 1 (channel catfish virus) (Herpesviridae) Infectious hematopoietic necrosis virus (Rhabdoviridae)

Infectious pancreatic necrosis virus (Birnaviridae)

infectious salmon anemia virus


Japanese eel iridovirus (Iridoviridae)

Japanese flounder nervous necrosis virus


Lates calcarifer encephalitis virus (Nodaviridae)

Oncorhynchus masou virus (Herpesviridae)

perch iridovirus (Iridoviridae)

perch rhabdovirus disease


pike fry rhabdovirus disease


red sea bream iridovirus (Iridoviridae) Redspotted grouper nervous necrosis virus (Nodaviridae)

Rio Grande cichlid virus (Rhabdoviridae) sheatfish iridovirus (Iridoviridae) smelt reovirus (Reoviridae) snakehead rhabdovirus (Rhabdoviridae) spring viremia of carp virus (Rhabdoviridae)

Striped jack nervous necrosis virus (Nodaviridae)

Tiger puffer nervous necrosis virus (Nodaviridae)

viral deformity virus (Birnaviridae) Viral hemorrhagic septicemia virus (Rhabdoviridae)

Agents of low virulence:

Atlantic cod epidermal hyperplasia (Adenoviridae)

bluegill hepatic necrosis reovirus (Reoviridae)

fishpox virus (Herpesviridae) golden shiner reovirus (Reoviridae) grouper reovirus (Reoviridae) Lymphocystis disease virus (Iridoviridae) walleye herpesvirus (Herpesviridae) Walleye dermal sarcoma virus (Retroviridae)

white sturgeon herpesvirus (Herpesviridae)

yellowtail ascites virus (Birnaviridae)

Bernard J and Bremont M (1995) Vet Res 26, 341

Herrick FM and Hedrick RP (1993) Annu Rev Fish Dis, p. 187

Kim CH and Leong J-A (1999) In Encyclopedia of Virology, Second edition, edited by A Granoff and RG Webster. London: Academic Press, p. 558

Nakajima K et al (1998) Fish Pathol 33, 181 Perez SI and Rodriguez S (1997) Microbiologia 13, 149

Wolf K (1988) Fish Viruses and Fish Viral Diseases. Cornell: Cornell University Press.

FIV-Oma See Feline immunodeficiency virus - Oma.

fixed virus Attenuated Rabies virus.

FL amnion cells (CCL 62) A heteroploid cell line derived from normal human amnion cells.

Flanders virus (FLAV) An unassigned species in the family Rhabdoviridae. With Hart Park, Kamese, Mosqueiro and Mossuril viruses forms the Hart Park serogroup. Isolated from mosquitoes, Culiseta melanura and Culex pipiens, and

flavivirus febricis from an ovenbird, Seiurus aurocapillus, in New York State, USA. Serologically similar viruses have been isolated from mosquitoes in Texas, California, Washington, a number of SE states of USA and Canada. Replicates in and kills newborn mice on i.c. injection but multiplies poorly if at all in embryonated eggs and cell cultures. Not known to be pathogenic in the wild.

Murphy FA et al (1966) Virology 30, 314

Flaviviridae A family consisting of three genera: Flavivirus, Pestivirus and Hepacivirus. Virions are spherical, 40-60nm in diameter, with a lipid envelope. The genome is a single molecule of linear positive-sense, single-stranded RNA, ranging from about 9 to 13kb in length. Structural proteins are encoded at the 5' end, and non-structural proteins at the 3' end. Except for a few tick-borne flaviviruses, there is no poly A tract at the 3' end of the genome. The biological properties of different viruses in the family vary widely.

Flavivirus A genus in the family Flaviviridae, consisting of about 55 anti-genically related viruses. Some multiply in mosquitoes and some in ticks with transovarial transmission, but others have no known arthropod host. Some replicate in eggs producing pocks on the CAM and in mouse embryo and HeLa cell cultures, but CPE is not invariably seen. Produce encephalitis on i.c. injection in mice; most are pathogenic on i.c. injection in rhesus and cynomolgus monkeys. The type species is Yellow fever virus. They can be subdivided according to their principal vectors (Table F1).

flavivirus febricis Synonym for Yellow fever virus.

Table F1. The flaviviruses

(1) The mosquito-borne species are: Aroa

Bagaza (H, R) Banzi" (C, H) Bouboui (C, A) Cacipacore (C) Dengue (C, H) Edge Hill (C, A) Ilheus" (C, H, B)

Israel turkey meningoencephalomyelitis (C) Japanese encephalitis' (C, A, H, B, Ba) Jugra (C, Ba) Kokobera (C) Koutango (C)

Murray Valley encephalitis' (C, H) Ntaya (C) Saboya (C) Sepik" (C)

Yaounde (C)

(2) The tick-borne species are: Gadget's Gully (I)

* Can cause disease in humans.

Kyasanur Forest disease' (I, Ag, H, R, B, Ba) Langat (I)

Omsk haemorrhagic fever* (I, H, R)

Royal Farm (Ag)

Saumarez Reef (I)

Tick-borne encephalitis (I)

Tyuleniy (I)

(3) The species never isolated from wild-caught arthropods:

Bukalasa bat (Ba)

Carey Island (Ba)

Cell fusing agent

Cowbone Ridge (R)

Dakar bat (Ba)

Entebbe bat (Ba)

Jutiapa (R)

Montana myotis leukoencephalitis (Ba)

Phnom Penh bat (Ba)

San Perlita (R)

Tamana Bat (Ba)

Yokose (Ba)

Isolated from: A, anopheline mosquitoes Ag, argasid ticks; Ba, bats; B, birds; C, culicine mosquitoes; I, ixodid ticks; H, man; M, marsupials; R, rodents.

Flexal virus (FLEV)

Flexal virus (FLEV) A species in the genus Arenavirus, a member of the Tacaribe complex. Isolated from Oryzomys rodents in Brazil in 1975. Not associated with disease in humans.

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  • edwin
    What is Fetal rhesus kidney virus?
    8 years ago

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