UdR See fluorodeoxyuridine

Fujinami sarcoma virus (FuSV) A species in the genus Alpharetrovirus. Obtained from a transplantable fowl tumor in 1914. A defective virus, with deletions in all three virion genes (env, gag and pol). Carries the oncogene fps, homologous to the mammalian feline sarcoma virus oncogene, fes. Both encode non-receptor tyrosine kinases. The tumor induced in chickens can be transplanted without difficulty into ducks.

Fujinami A and Inamoto K (1914) Z Krebsforsch 14,94

Fukuoka virus (FUKAV) An unassigned species in the family Rhabdoviridae belonging to the Kern Canyon serogroup. Isolated in cultures of HmLu-1 cells derived from baby hamster lung from blood samples of four sentinel calves having a fever and leukopenia.

Noda M et al (1992) Vet Microbiol 32, 267

fusin A human membrane protein involved in the penetration of the HIV-receptor complex into the cell.

Feng Y et al (1996) Science 272, 872

fusion of cells The formation of multi-nucleate giant cells known as poly-karyocytes or syncytia. Can be caused by a variety of agents including some viruses, notably Paramyxoviridae. There are two types of virus-induced fusion. (1) Fusion from without. Not dependent on virus replication or on the synthesis of new proteins. Occurs not more than 1-3 h after exposure to high multiplicities of most of the large enveloped RNA viruses or certain DNA viruses such as Human herpesviruses 1 and 2 and Vaccinia virus, even when they have been inactivated by UV light or P-propiolactone. May also be caused by viral hemolysin, since treatment which will destroy this enzyme activity without affecting viral infectivity will also prevent the cell-fusing action. (2) Fusion from within. Begins several hours after infection and depends on synthesis of viral proteins, especially the F protein of paramyx-oviruses. Production of new infectious virus is not necessary. Often most marked after infection at low virus multiplicity. The mechanism may be the same as fusion from without. Fusion from within can be prevented late in infection by antiviral antibody.

Falconer MM et al (1995) J Virol 69, 5582

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