Gibbon ape type C oncovirus See Gibbon ape leukemia virus

Girardi heart cells (CCL 27) A heteroploid cell line established from the right atrial appendage of a 41-year-old human male in 1956. The cells grew as fibroblasts at first, but after about 18 weeks they became epithelial-like.

Girard Point virus An isolate of Hantaan virus.

glandular fever virus Synonym for Human herpesvirus 4.

gliotoxin A common fungal metabolite which inhibits viral RNA-dependent RNA synthesis without effect on DNA-depend-ent RNA synthesis. Prevents human poliovirus replication in HeLa cells.

Miller PA et al (1968) Science 159, 431

gloves and socks syndrome A petechial or papular-purpuric rash on the hands and feet of children and adults. Following infection there is acute onset of fever, exanthem, edema and erythema of the hands and feet that has been associated with parvovirus B19 infection syndrome; has also been described in relation to cytomegalovirus infection.

Carrascosa JM et al (1995) Dermatology 191,269 Halasz CLG et al (1992) J Am Acad Dermatol 27, 835

glugea lyssae Name given to a supposed protozoan etiological agent of rabies. The structure is now known as the 'Negri body'.

Levaditi C et al (1924) C R Acad Sci Paris 178, 256

glycoproteins Proteins with covalently attached sugars, bound either through the OH group of serine or threonine (O-gly-cosylation) or through the amide NH2 of asparagine (N-glycosylated). Most virus proteins that bud through the surface membrane are glycosylated. Although N-glycosylation is the most common, O-glycosylation is found with some viruses, notably coronaviruses. The sugar residues found on virus glycoproteins include fucose, galactosamine, galactose, glucosamine, mannose and sialic acid.

glycosylation The addition of sugars to proteins.

glycyrrhizic acid An antiviral agent derived from the roots of the liquorice plant, Glycyrrhiza glabra. The ammonium salt completely inhibited growth and CPE of vaccinia, Human herpesvirus 1, Newcastle disease and Vesicular stomatitis viruses when grown in cultures of HEp-2 cells. There was no effect on poliovirus type 1. In addition to the inhibitory action, there is irreversible inactivation of Human her-pesvirus 1, although not of the other viruses tested. The mode of action of gly-cyrrhizic acid is not understood, but it is not thought to be mediated through damage to host cells.

Pompei R et al (1979) Nature 281, 689

goat adenovirus 1, 2 (GAdV-1, 2) Serotypes of caprine adenovirus, a tentative species in the genus Mastadenovirus.

goat capripoxvirus See Goatpox virus.

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