Hydroxyethoxymethylguanine See acycloguanosine

hydroxyphosphonylmethoxycytosine (HPMPC) An antiviral compound, also known as cidofovir, which appears to be active against several species of her-pesviruses.

hyperchromic effect Increase in absorbance of light of wavelength 260nm by DNA at the melting point or transition temperature.

hyperimmune serum Serum from an animal which has received two or more injections of a foreign antigen for the purpose of producing a reagent for use in serology.

hypersensitivity A state of altered reactivity in which the body reacts with an exaggerated immune response to a foreign substance. Hypersensitivity reactions can be immediate or delayed.

hypertrophy Increase in the size of an organ or tissue, e.g. mumps virus infection of the lymph nodes.

hypovolemia An abnormally decreased volume of circulating fluid, especially plasma, in the body.

Hypr virus (HYPRV) A strain of tick-borne encephalitis virus in the genus Flavivirus. Isolated from a boy with encephalitis in Brno, Moravia. Antigenically very similar or identical to Hanzalova virus, in the serogroup tick-borne encephalitis virus (Central European subtype). Frequent human infections in Hungary, Poland, the former Yugoslavia, Austria, Bulgaria, Sweden and Finland. Distinguished by slow growth rate, narrow host range and high degree of cell association. Can often be isolated from the kidney, and with particular frequency from the salivary glands. It is likely that viruses of this group might be found in all mammalian species were an adequate search to be made. They have already been demonstrated in humans, mouse, ground squirrels, guinea pigs, various primates, rats, horses and pigs.

I10 cells (CCL 83) A cell strain, initiated from a mouse BALB/c Leydig cell testic-ular tumor, which secretes progesterone and its derivative.

Iaco virus (IACOV) A strain of Bunyamwera virus in the genus Bunyavirus. Isolated from mosquitoes, Wyeomyia sp. Not associated with disease in humans.

Ibaraki virus (IBAV) A serotype of Epizootic hemorrhagic disease virus in the genus Orbivirus. Isolated from cattle in Ibaraki Prefecture, Japan. Resembles Bluetongue virus, from which it is antigenically distinct, in causing a disease (often severe) in cattle in Japan, but with little pathogenicity for sheep. Probably transmitted by arthropods. Replicates in bovine cell cultures with CPE and in the yolk sac of embry-onated eggs. Not pathogenic for guinea pigs or rabbits. Not to be confused with Bovine ephemeral fever virus which causes a somewhat similar disease. Found in Japan, Bali and Taiwan. A live attenuated Ibaraki virus vaccine is produced in Japan. Synonym: Keishi virus.

Ito Y et al (1973) Arch Ges Virusforsch 40, 29

IBDV See Infectious bursal disease virus.

IBV See Infectious bronchitis virus.

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