Isoelectric focusing electrofocusing A

separation technique in which mixtures of proteins and/or viruses are resolved into their components by subjecting them to an electric field in a supporting gel or stabilized solution in which a pH gradient is established. The proteins or viruses migrate to the positions in the gel which have a pH equivalent to their isoelectric points.

isoelectric point The pH value of a solution in which a given macromolecule (usually a protein or virus) does not move in an electric field. At this pH the net surface charge is zero.

isolate A virus propagated in pure culture as far as is known. May later prove to be a mixture. Often used incorrectly to describe what would be better known as a recognizate.

isometric particle Particles with identical linear dimensions, distinct from the rod-shaped and bullet-shaped virus particles and viruses enclosed by irregular capsules. They appear spherical; however, their capsids are constructed with icosa-hedral symmetry.

Isoprinosine Trade name for inosiplex.

isopycnic gradient centrifugation A form of density gradient centrifugation in

IUMS

which the supporting gradient column includes the entire range of densities of the particles to be tested. In this case, sedimentation of an individual particle will cease when it reaches that point in the gradient matching its own density, i.e. the point of buoyant density. Separation of particles into zones by this technique depends only upon their density differences and is independent of time. See also rate zonal centrifugation.

isotype An antigenic determinant shared by all individuals of a given species but absent in individuals of other species.

Israel turkey meningo-encephalitis virus

(ITV) A species in the genus Flavivirus. Isolated from domestic turkeys in Israel. Causes a progressive paralysis with meningo-encephalitis leading to 10-12% mortality. An attenuated vaccine is commercially available, and in enzootic areas such as Israel is given by i.m. injection at 8 weeks. Not associated with human disease.

Malkinson M (1993) In Virus Infections of Birds, edited by JB McFerran and MS McNulty. Amsterdam: Elsevier Science Publishers, p. 239

Issyk-Kul virus (IKV) An unassigned virus in the family Bunyaviridae. Isolated from bats and ticks in Kirghiz, former USSR. Antibodies are found in humans but the virus is not reported to cause disease. Synonym: Keterah virus.

Itaboca virus A possible species in the genus Orbivirus, isolated from phle-botomine sandflies in the Amazon region of Brazil. Antigenically related to Changuinola virus. Not known to cause disease in humans.

Itacaiunas virus An unclassified arbovirus isolated from a pool of Culicoides midges in the Amazon region of Brazil. Not known to cause disease in humans.

Itaituba virus (ITAV) A strain of Candiru virus in the genus Phlebovirus. Isolated from an opossum, Didelphis marsupialis in Brazil. Not associated with disease in humans.

Itakura virus An isolate of Sagiyama virus, a serotype of Ross River virus in the genus Alphavirus. Isolated in Japan.

Itaporanga virus (ITPV) A tentative species in the genus Phlebovirus. Isolated from mosquitoes of Culex sp. Natural hosts inhabit the forest canopy, e.g. bats and birds. Forest floor animals are not infected. Found in Sao Paulo, Amapa and Para, Brazil, and in Trinidad and French Guiana. Not reported to cause disease in humans.

Itaqui virus (ITQV) A strain of Oriboca virus in the genus Bunyavirus and a member of the group C viruses. Isolated from sentinel cebus monkeys and mice, forest rodents and marsupials in Para, Brazil. Mosquito-borne. Causes CPE in HeLa cell cultures. Not reported to cause disease in humans.

Iteravirus A genus of invertebrate par-voviruses in the subfamily Densovirinae.

Itimirim virus (ITIV) A strain of Bertioga virus in the genus Bunyavirus. Isolated from a rodent, Oryzomys sp.

Itupiranga virus (ITUV) A tentative species in the genus Orbivirus. Isolated from mosquitoes in the Amazon region of Brazil. Not known to cause disease in humans.

IUBS International Union of Biological Sciences.

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