LaPiedad MichoacanMexico virus LPMV

Synonym for Porcine rubulavirus; pig's blue eye disease.

Lapine parvovirus (LPV) A species in the genus Parvovirus, isolated from rabbit feces. Replicates and produces CPE in rabbit kidney cell cultures. Agglutinates human group O erythrocytes at 4°C. Stable at pH 3, resistant to chloroform and to heating at 60°C for 30 mins. No cross-reaction with latent rat virus in HI tests. In a survey in the USA, 75% of rabbits were seropositive for parvovirus infection, and virus could be recovered from the kidneys of neonatal rabbits. Synonym: rabbit parvovirus.

Gregg DA and House CA (1989) Vet Rec 125, 603 Matsunaga Y et al (1977) Infect Immun 18, 495 Stout ER and Bates RC (1989) Am J Vet Res 50, 1048

lapinized virus Virus adapted to rabbits.

When Rinderpest virus is so adapted it ceases to be virulent for cattle.

largemouth bass virus (LMBV) A tentative species in the genus Ranavirus. Has caused recent outbreaks of disease in lakes and reservoirs in Texas and several other Southern United States. Zilberg D et al (2000) Dis Aquat Org 39, 143

laryngeal papillomatosis

laryngeal papillomatosis A juvenile disease with growth of benign squamous cell papillomas in the larynx and trachea which can lead to narrowing of the airway, requiring excisions. The papillo-mas are recurrent and usually require multiple excisions. Caused in childhood by Human papillomavirus, usually ano-genital types such as HPV6 and HPV11, probably acquired from mothers suffering from condyloma acuminatum.

Las Maloyas virus (LMV) A serotype of Anopheles A virus in the genus Bunyavirus. Isolated from mosquitoes, Anopheles albitar-sis. No evidence of disease in humans.

Lassa virus (LASV) A species in the genus Arenavirus. Causes severe human hemor-rhagic fever in W Africa (Nigeria, Liberia, Guinea and Sierra Leone). Onset is insidious: 4 days of malaise, headache, fever, followed by severe limb and back pains, diarrhea, vomiting and severe prostration greater than expected from the degree of fever. Sore throat with white patches overlaid by red membrane. Low blood pressure. Temperature settles in 2 weeks. An estimated 300000 cases occur annually in W Africa, causing up to 5000 deaths. In hospitalized patients, the mortality is 15-20%. Infectivity survives 1 h at 56°C. The field rat, Mastomys natalensis, the natural host, comes into villages in the winter when most cases occur. Lassa fever virus can establish a persistent tolerant infection in this species, with copious shedding of virus in urine. Human contact with the rats or their excreta may result in infection. Close contact is probably required for case-to-case transmission in humans, but periodically iatrogenic cases or nosocomial outbreaks occur due to poor clinical practices. Both ribavirin and human convalescent serum have been found to be useful in treatment. Mice can be infected and produce antibodies, but develop no signs except that some adults on stimulation may have tonic convulsions. May be isolated in guinea pigs. Liver infection diagnosed by fluorescent antibody. Liver biopsy may show virus on electron microscopy. Replication in Vero cells can be detected by fluorescent antibody. Three strains, Josiah, Nigeria and AV, have been completely sequenced.

Bowen MD et al (2000) J Virol 74, 6992 Childs JE and Peters CJ (1993) In The Arenaviridae, edited by MS Salvato. New York: Plenum Press, p. 331 Gunther S (2000) Emerg Infect Dis 6,466

late genes Genes that are normally expressed late in infection, after replication of the genome has commenced.

late proteins Virus proteins produced in infected cells after the replication of the viral genome has commenced. They are mainly structural proteins of the virus particle.

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