Lymphoproliferative herpesvirus group

Synonym for Gammaherpesvirinae.

lymphotropic papovavirus A species in the genus Polyomavirus. Isolated from a B-lymphoblastic cell line derived from an African green monkey. Grows only in dividing B lymphocytes.

lyophilization Rapid freezing of a material at low temperature accompanied by rapid dehydration by sublimation in a high vacuum. A method used to preserve biological specimens or to concentrate macromolecules with little or no loss of activity.

Synonym: freeze-drying.

lysis from without Lysis due to adsorption of a large number of virus particles to the host cell surface.

lysogenic Having a prophage integrated into the bacterial genome. The prophage may become activated spontaneously or under the influence of certain stimuli, when it will replicate phage particles and destroy the cell, releasing infective bacte-riophage. Lysogenic bacteria may have certain properties determined by the prophage, such as diphtheria toxin production or antigens.

lyssa virus Synonym for Rabies virus.

Lyssavirus A genus of the family Rhabdoviridae. Morphologically similar to species in the genus Vesiculovirus but antigenically distinct. The viral envelope may be formed within the cytoplasm or by budding from the plasma membrane. Virions agglutinate goose erythrocytes. There is serological cross-reaction between species, but the viruses can be grouped into four serotypes or seven genotypes. Type species is Rabies virus. Other species are Australian bat lyssavirus, Duvenhage virus, European bat lyssavirus 1, European bat lyssavirus 2, Lagos bat virus and Mokola virus. Rochambeau virus is a tentative species in the genus. The arthropod isolates, Kotonkan and Obodhiang viruses, formerly assigned to the genus,


have features in common with members of the Ephemerovirus genus, and are presently unassigned viruses within the family Rhabdoviridae.

Bourhy H et al (1993) Virology 194, 70 Jallet C et al (1999) J Virol 73, 225 Rupprecht CE et al (1994) Curr Top Microbiol Immun 187, 352 pp

Tordo N et al (1998) In Virology, vol. 1 of Topley & Wilson's Microbiology and Microbial Infections, Ninth edition, edited by BWJ Mahy and LH Collier. London: Arnold, p. 665

lytic cycle A term usually applied to the productive replicative cycle in virus infections (particularly phage) which ends with the production of progeny virus particles and their release from the host, most usually by lysis of the host cells.

lytic viruses Viruses whose replication causes destruction (lysis) of the host cell.

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