NAAT Nucleic acid amplification technique.

N-acetylneuraminic acid A compound derived from acetic acid, mannosine and pyruvic acid that is a major constituent of eukaryotic cell membranes. See neu-raminidase. Synonym: sialic acid.

NAD Nicotinamide adenine dinucleotide. Formerly known as diphosphopyridine nucleotide, DPN, coenzyme I or cozymase.

NADP Nicotinamide adenine dinucleotide phosphate, coenzyme II.

Nagata strain of fecal virus A strain of virus found in Japan, related to Norwalk virus.

Nairobi sheep disease virus (NSDV) A

species in the genus Nairovirus. Found in Kenya, Uganda, Congo, Ethiopia, Somalia and Tanzania. Causes a non-contagious hemorrhagic gastroenteritis in sheep and goats with high mortality. There is splenic enlargement and involvement of the female genital tract. Nephritis and myocardial degeneration occur. Causes encephalitis in mice inoculated i.c. Transmitted by the tick, Rhipicephalus appendiculatus. Virus replicates in cell cultures of lamb and goat tissue with CPE. Cases of human infection with fever and arthralgia have been reported, as well as cases of serological conversion without disease.

Davies FG et al (1978) J Comp Pathol 88, 519

Nairovirus A genus in the family Bunyaviridae, containing more than 30 viruses, including the important Crimean-Congo hemorrhagic fever and Nairobi sheep disease viruses. Nairoviruses are morphologically similar and have no antigenic cross-reaction with other genera in the family Bunyaviridae. The genome is single-stranded negative-sense RNA in three segments, each of which have the sequence AGAGUUUCU at the 3' terminus and UCUCAAAGA at the 5'

terminus. There are eight recognized virus species: Crimean-Congo hemorrhagic fever virus, Dera Ghazi Khan virus, Dugbe virus, Hughes virus, Nairobi sheep disease virus, Qalyub virus, Sakhalin virus and Thiafora virus.

naked viruses Viruses without a lipo-protein envelope.

NANB hepatitis virus Synonym for non-A non-B hepatitis virus (e.g. Hepatitis C virus).

Nandi virus A strain of Mouse mammary tumor virus, of low oncogenicity, in the genus Betaretrovirus. Isolated from C3H mice. Also known as MTV-L and NIV.

Naranjal virus (NJLV) A strain of Aroa virus in the genus Flavivirus. Isolated from a sentinel hamster.

Nariva virus An unassigned virus in the family Paramyxoviridae isolated from forest rodents in Trinidad. Morphologically and biologically similar to viruses of the family. Kills newborn mice on i.c. injection. Hamsters and guinea pigs produce antibodies but develop no disease. No isolations from arthropods. Not reported to cause disease in humans.

Tikasingh ES et al (1966) Am J Trop Med Hyg 15, 235

nascent In the process of being synthesized.

nascent cleavage Cleavage of a polyprotein occurring at the same time as it is being synthesized by cell ribosomes.

nascent RNA RNA in the process of being synthesized.

Nasoule virus (NASV) An unassigned vertebrate rhabdovirus. Isolated from the bird, Andropadus virens, in Central African Republic.

Sureau P (1974) Institut Pasteur Bangui,

Annual Report, 37

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