Pheasant adenovirus 1 PhAdV1 A

species in the genus Aviadenovirus. Causes marble spleen disease in the ring-necked pheasant, Phasianus colchicus. Can be transmitted experimentally to turkeys.

Iltis JP and Daniels SB (1977) Infect Immun 16, 701

pheasant leukosis virus A possible species in the genus Alpharetrovirus. Endogenous virus present in pheasant cells and capable of acting as helper virus for defective Rous sarcoma virus. Envelope-characterized specificities of the virus from ring-necked pheasants, Phasianus colchi-cus, were group F, while those of the virus from golden pheasants, Chrysolophus pictus, were group G.

Fujita DJ et al (1974) Virology 60, 558

phenotype The outward, observable characteristics of a virus determined by its genotype.

phenotypic mixing The production, in a mixed infection, of progeny virus with phenotypic characters from two genetically different viruses, but with a genome derived from only one of them. The phenomenon is particularly common in viruses which mature by budding through the cell membrane. The defective avian and mammalian sarcoma viruses are usually phenotypically mixed since their envelope proteins are coded for by a helper virus. Another form of phenotypic mixing is the formation of pseudotype virus, where nucleocapsids of one virus are enclosed in the envelope of another virus. In an extreme case, where the genome of one virus is enclosed in a capsid coded for by another, it is described as transcapsida-tion (see adenovirus-SV40 hybrids) or genomic masking. Phenotypic mixing has also been accomplished artificially by physical encapsidation of the genome of mouse sarcoma virus with the envelope of Feline leukemia virus by ultracentrifu-gation of a mixture of the two viruses.

Boettiger D (1979) Prog Med Virol 25, 37 Fischinger PJ and O'Connor TE (1969) Science 165, 714

Zavada J (1976) Arch Virol 50, 1

n-phenylacetoaminomethylene-DL-p-nitro-phenylalanine An antiviral agent. An amino acid-related compound. Prolongs survival time and reduces splenomegaly in mice injected with Friend leukemia virus. Reduces the yield of Friend and Moloney leukemia virus in mouse cell cultures. Mechanism of action not clear.

Fujita H et al (1979) J Natl Cancer Inst 62, 565

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