Phlebotomus fever serogroup An old

grouping of viruses within the genus Phlebovirus which included Rift valley fever virus, Sandfly fever Naples virus and others which are serologically related.

phlebotomus fever viruses Five viruses (Candiru, Chagres, Punta Toro and Sandfly fever viruses of Naples and Sicilian types) can cause phlebotomus fever in humans, although only SF-Naples virus and SF-Sicilian virus have caused large outbreaks. They are anti-genically distinct from each other. Isolated from humans in Italy, Egypt, Iran and Pakistan. Cause short, sharp fever after an incubation period of 2-4 days. Fever may be recurrent, there is infection of the conjunctiva and pain in the eyes, head, back and limbs. Gastro-intestinal symptoms occur. There is leukopenia. No fatalities have been reported. Not known to cause disease except in humans. The sandfly, Phlebotomus papatasi, is the vector. Mouse-adapted virus given i.d. to humans produces immunity but no disease. However, prevention is usually by control of the vector. Replicate in human, mouse and hamster kidney cell cultures with CPE. Diagnosis confirmed by rising antibody titer or by virus isolation from blood in early stages of disease. Synonyms: hundskrankheitvirus; pappat-aci fever viruses; sandfly fever viruses.

Phlebovirus A genus in the family Bunyaviridae containing nine species, Bujaru, Candiru, Chalibre, Frijoles, Punta

Toro, Rift Valley fever, Salehabad, Sandfly fever Naples and Uukuniemi viruses. The surface morphology is distinct in having small round subunits with a central hole. Transmission may be by flies, mosquitoes or ticks, depending on the species. The nine species are based upon antigenic groups, but all Phleboviruses have common coding and transcriptional strategies. The negative-stranded RNA genome segments have a 3'-terminal UGUGUUUC and 5'-terminal ACACAAG sequence. The S RNA is ambisense and encodes the N protein in negative sense and a non-structural protein (NSs) in positive sense.

Phnom Penh bat virus (PPBV) A species in the genus Flavivirus in the Rio Bravo virus group. Isolated from bats in Cambodia. No known arthropod vector. Not reported to cause disease in humans.

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