Receptordestroying enzyme RDE See neuraminidase

receptor-mediated endocytosis A process by which many viruses gain entry to the cell. In order to fuse with the cell membrane a mildly acid environment is required (pH 5-6). The virus enters the cell by receptor-mediated endocytosis into endosomes whose contents become acidified by an ATP-driven proton pump. The virus fuses with the membrane of the endosome and releases the viral genome into the cytoplasm.

recognizate A term proposed, but not widely adopted, to describe the demonstration of the presence of a virus, and its recognition without it having been cultivated in pure culture. Cf. isolate.

Madeley CR and Kay CJ (1978) Lancet ii, 733

recombinant DNA DNA molecules containing novel sequences, formed by in vitro recombination with non-homologous molecules.

recombinant RNA RNA virus genomes constructed by genetic engineering of infectious DNA clones. Intertypic chimeras of polioviruses have been constructed in this way.

recombinants Viruses containing nucleic acid sequences from two or more different virus genomes. They may be formed in either of two ways: intramolecular recombination, which involves transfer of sequences within single molecules of nucleic acid, or genetic reassortment, in which viruses whose genomes are fragmented into a number of pieces (e.g. Arenaviridae, Bunyaviridae, Orthomy-xoviridae or Reoviridae) exchange whole pieces (segments) of RNA.

recombination The exchange of genetic material from two or more virus particles into recombinant progeny virus during a mixed infection.

reovirus-like agent red deer herpesvirus Synonym for Cervid herpesvirus 1.

red disease of pike virus Synonym for pike fry rhabdovirus.

redfin perch virus (RFPV) A strain of Epizootic hematopoietic necrosis virus, a tentative species in the genus Ranavirus.

red kangaroo poxvirus (KPV) An unas-signed virus in the family Poxviridae.

red nose virus Synonym for Bovine her-pesvirus 1.

red sea bream iridovirus A possible species in the family Iridoviridae. Causes an acute highly contagious disease with high mortality in cultured red sea bream in south-west Japan. Affected fish have severe anemia, petechiae of the gills, and enlargement of the spleen. A virus which appears to be an iridovirus can be cultured from diseased fish on various fish cell lines. An effective formalin-killed vaccine given by i.p. inoculation has been described.

Matsuoka S et al (1995) Fish Pathol 31, 115 Nakajima K et al (1999) Dis Aquat Org 36, 73

Redspotted grouper nervous necrosis virus (RGNNV) A species in the genus Betanodavirus.

Redwood Park virus (RPV) A tentative species in the genus Ranavirus. Synonyms: Stickleback virus; tadpole virus 2.

Reed Ranch virus (RRV) An unassigned species in the family Rhabdoviridae, belonging to the Bahia Grande serogroup. Isolated from mosquitoes, Culex salinarius, in Texas, USA in 1974. Not associated with disease in humans.

Reed-Sternberg cells Giant histiocytes, typically multinucleate or binucleate that contain prominent nucleoli and are commonly seen in Hodgkin's disease, where they may be infected by Epstein-Barr virus.

regina ranavirus (RRV) A tentative species in the genus Ranavirus.

reindeer herpesvirus Synonym for cervid herpesvirus 2.

reindeer papillomavirus (RePV) A possible species in the genus Papillomavirus isolated from the epithelial layer of a cutaneous fibropapilloma on a Swedish reindeer, Rangifer tarandus. Morphologically indistinguishable from other papillomaviruses, but the restriction enzyme cleavage pattern of its genome is different. RePV is oncogenic for hamsters and transforms C127 mouse cells in vitro. Transforming properties correlate with a highly conserved E5 region.

Moreno-Lopez J et al (1987) J Virol 61, 3394

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