Reiterated sequence See repeated sequence

Relenza An inhaled anti-neuraminidase drug effective against influenza.

Reoviridae (acronym: respiratory, enteric, orphan) A family of unenveloped double-stranded RNA viruses infecting vertebrates, invertebrates, higher plants, bacteria and fungi. The term 'reovirus' was coined by Albert Sabin in 1959 because the human respiratory and enteric isolates were 'orphans', i.e. not associated with disease. Virion has an isometric two-layered capsid with icosahedral symmetry, 60-80nm in diameter, usually naked but pseudomembranes, probably of host origin, are described. Buoyant density (CsCl): 1.31-1.38g/ml; 630S. Virion contains an RNA-dependent RNA polymerase. The RNA genome is in 10, 11 or 12 segments of total mol. wt. 12-20 x 106, all within a single virion. G+C content 42-44%. Resist lipid solvents. Genetic reassortment occurs readily within genera. Viral synthesis and maturation occur in the cytoplasm. Inclusion bodies with crystalline arrays of virus particles are often seen. The vertebrate species are in five genera: Orthoreovirus, Orbivirus, Rotavirus, Coltivirus and Aquareovirus. There are also four genera of insect and plant viruses.

Joklik WK (1985) Annu Rev Gen 19, 537 Nibert ML et al (1991) J Clin Invest 88, 727

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